大鼠分次局部照射后大肠狭窄
Large bowel stenosis in rats after fractionated local irradiation.
作者信息
Kiszel Z, Spiethoff A, Trott K R
出版信息
Radiother Oncol. 1984 Oct;2(3):247-54. doi: 10.1016/s0167-8140(84)80065-1.
PMID:6528058
Abstract
After local irradiation of the distal large bowel rats may develop fatal large bowel stenosis within 200 days. The incidence rises steeply with dose. The LD50 for single dose irradiation is 20 Gy. The tolerance of the large bowel to local irradiation depends strongly on dose fractionation. Extending the intervals between the fractions and decreasing the dose per fraction both have a pronounced dose-sparing effect.
摘要
对大鼠远端大肠进行局部照射后，200天内可能会发生致命的大肠狭窄。发病率随剂量急剧上升。单次照射的半数致死剂量为20戈瑞。大肠对局部照射的耐受性在很大程度上取决于剂量分割。延长分割间隔并降低每次分割的剂量都具有显著的剂量节省效应。
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