Viveiros D M, Tondat L M
Pharmacol Biochem Behav. 1978 Feb;8(2):125-7. doi: 10.1016/0091-3057(78)90327-1.
Ffteen Sprague-Dawley rats were administered sodium nitrite 0.13% or 0.15% solutions in their drinking water from the age of 45 days to the end of the study. Six control rats received only tap water. At 80 days of age, rats were trained to bar press for food pellets on a CRF schedule. After reaching criterion performance the rats were switched to a DRL-20 for a period of 6 days to test for response inhibition, which was measured as a ratio of responses to reinforcements. Results indicated no significant differences between groups for response inhibition. All groups showed significant increases in learning as reflected by a decrease in ratios and an increase in total reinforcements over days. However, sodium nitrite rats compared to controls obtained significantly fewer reinforcements over sessions and a greater number of no responding periods (time-outs). One interpretation discussed was the possibility that sodium nitrite produced an increase in responding to distractible (non-task related) cues.
15只斯普拉格-道利大鼠从45日龄开始直至研究结束，饮用含0.13%或0.15%亚硝酸钠的溶液。6只对照大鼠只饮用自来水。在80日龄时，训练大鼠按照连续强化程序按压杠杆以获取食丸。达到标准表现后，将大鼠转换为20秒间隔强化程序，持续6天以测试反应抑制，反应抑制通过反应与强化的比率来衡量。结果表明，各实验组在反应抑制方面无显著差异。所有实验组均显示出学习能力的显著提高，表现为随着时间推移比率下降和总强化次数增加。然而，与对照组相比，亚硝酸钠组大鼠在各实验阶段获得的强化显著减少，无反应期（超时）更多。所讨论的一种解释是，亚硝酸钠可能导致对分散注意力（与任务无关）线索的反应增加。
