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[兔血浆脂蛋白与肠系膜淋巴的比较特征:光谱及化学性质]

[Comparative characteristics of plasma lipoproteins and mesenteric lymph in the rabbit: spectrum and chemical properties].

作者信息

Denisenko A D, Lozovskiĭ V T, Bergmann S, Iaros V, Klimov A N

出版信息

Vopr Med Khim. 1984 Sep-Oct;30(5):65-72.

PMID:6528523
Abstract

Rabbit mesenteric lymph contained all the main classes of lipoproteins detected in plasma: chylomicrons (CM), very low density lipoproteins (VLDL), low density lipoproteins (LDL), high density lipoproteins (HDL). The main classes of lipoproteins in lymph were CM and VLDL, whereas LDL and HDL were the main lipoproteins in blood plasma. The heaviest subfractions HDL3 were not observed in mesenteric lymph. Lymph contained only low amount of LDL; molecular mass of lymphatic LDL was lower as compared with the blood plasma lipoproteins. Mesenteric lymph lipoproteins were enriched with triglycerides and contained less cholesterol, phospholipids and protein than the corresponding blood plasma lipoproteins. As distinct from blood plasma lipoproteins, apo E and apoproteins of low molecular mass (apo C?) were not found in lymphatic lipoproteins. Content of Apo-I was much higher in lymphatic VLDL as compared with the blood plasma VLDL. The dissimilarity in patterns and composition between blood plasma and lymphatic lipoproteins indicated that the latter were derived from intestine. Thus, intestine was able to produce CM, VLDL, HDL2 and apparently a small amount of LDL.

摘要

兔肠系膜淋巴液中含有血浆中检测到的所有主要脂蛋白类别

乳糜微粒(CM)、极低密度脂蛋白(VLDL)、低密度脂蛋白(LDL)、高密度脂蛋白(HDL)。淋巴液中的主要脂蛋白类别是CM和VLDL,而LDL和HDL是血浆中的主要脂蛋白。在肠系膜淋巴液中未观察到最重的亚组分HDL3。淋巴液中仅含有少量的LDL;与血浆脂蛋白相比,淋巴液中LDL的分子量较低。肠系膜淋巴脂蛋白富含甘油三酯,与相应的血浆脂蛋白相比,胆固醇、磷脂和蛋白质含量较少。与血浆脂蛋白不同,在淋巴脂蛋白中未发现载脂蛋白E和低分子量载脂蛋白(载脂蛋白C?)。与血浆VLDL相比,淋巴液中VLDL的载脂蛋白I含量要高得多。血浆脂蛋白和淋巴脂蛋白在模式和组成上的差异表明,后者来源于肠道。因此,肠道能够产生CM、VLDL、HDL2,显然还能产生少量的LDL。

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