Schwarz N, Redl H, Schlag G, Lintner F, Dinges H P, Thurnher M, Schiesser A
Arch Orthop Trauma Surg (1978). 1987;106(2):113-9. doi: 10.1007/BF00435424.
An experimental study in rats was done to investigate the bone-regenerating properties of collagen apatite (Collapat) and to compare it with osteoinduction dependent on osteogenin-containing gelatine (OCG). The test substances were implanted orthotopically (calvarial defect--7 mm in diameter) and heterotopically (paravertebral muscles, abdominal muscles). The results were evaluated histologically and enzymatically (alkaline phosphatase). Collapat caused neither osteoinduction in the heterotopic site nor healing of the bone defects. Foreign body reaction without new bone formation was encountered. OCG implantation leads to new bone formation in the muscles within 3 weeks, associated with a significant increase in alkaline phosphatase activity, and to extensive new bone formation in the calvarial defect within 4 weeks. The defects did not heal if left empty. The value of clinical application of Collapat appears to be doubtful. Osteoinduction with OCG requires further experimental investigation.
在大鼠身上进行了一项实验研究，以探究胶原磷灰石（Collapat）的骨再生特性，并将其与依赖含骨生成素的明胶（OCG）的骨诱导作用进行比较。将测试物质原位植入（颅骨缺损——直径7毫米）和异位植入（椎旁肌、腹肌）。通过组织学和酶学（碱性磷酸酶）评估结果。Collapat在异位部位既未引起骨诱导，也未使骨缺损愈合。出现了无新骨形成的异物反应。植入OCG在3周内导致肌肉中形成新骨，碱性磷酸酶活性显著增加，并在4周内使颅骨缺损处形成大量新骨。缺损若不处理则不会愈合。Collapat的临床应用价值似乎存疑。OCG的骨诱导作用需要进一步的实验研究。
