Osborn J F, Newesely H
Biomaterials. 1980 Apr;1(2):108-11. doi: 10.1016/0142-9612(80)90009-5.
Tricalcium, tetracalcium phosphate and hydroxyapatite ceramics exhibit distinct differences in their chemical and structural composition. Only hydroxyapatite ceramic is identical with the original bone mineral. Different preparation methods lead to compact hydroxyapatite ceramic or to porous material with interconnecting macropores as structural equivalents of the spatial structure of cancellous bone. Concerning the behaviour in a biological environment, high crystallinity and large material density result in resistance to dissolution and long lasting stability. Amorphous ultrastructure and porous formation enhance interface activity and bone ingrowth, but also biological degradation of the ceramic implant material.
磷酸三钙、磷酸四钙和羟基磷灰石陶瓷在化学和结构组成上表现出明显差异。只有羟基磷灰石陶瓷与原始骨矿物质相同。不同的制备方法会导致形成致密的羟基磷灰石陶瓷或具有相互连通的大孔的多孔材料，这些大孔作为松质骨空间结构的结构等效物。关于在生物环境中的行为，高结晶度和大材料密度导致抗溶解和长期稳定性。无定形超微结构和多孔形成增强了界面活性和骨向内生长，但也会导致陶瓷植入材料的生物降解。
