Basler A
Basic Life Sci. 1984;29 Pt B:595-8. doi: 10.1007/978-1-4684-4892-4_8.
Rats were treated intraperitoneally (ip) with 13.3 mg cyclophosphamide (CP)/kg. Blood was obtained by cardiac puncture 6,24,48,72 hr, 5 da and after treatment. The spontaneous sister chromatid exchange (SCE) frequency (9.94 SCEs/cell) was 4-fold increased (40.49 SCE/cell) in lymphocyte cultures set up 24 hr, after the CP treatment. Within the next 24 hr the SCE frequency began to decline and by 2 wk post-treatment the SCE values were within the control range. The results indicate that the elimination of damage to DNA by existing repair mechanisms is responsible for the reduction of SCEs with time, in addition to lymphocyte turnover.
给大鼠腹腔注射（ip）13.3毫克/千克环磷酰胺（CP）。在治疗后6小时、24小时、48小时、72小时、5天及之后通过心脏穿刺取血。在CP治疗后24小时建立的淋巴细胞培养物中，自发姐妹染色单体交换（SCE）频率（9.94个SCE/细胞）增加了4倍（40.49个SCE/细胞）。在接下来的24小时内，SCE频率开始下降，到治疗后2周时，SCE值在对照范围内。结果表明，除淋巴细胞更新外，现有修复机制消除DNA损伤是SCE随时间减少的原因。
