Some studies on the enzyme lecithin-cholesterol acyl-transferase in rat plasma.

The results presented in this study, which include different physiological and pathological conditions, show: 1--In the rat subjected to bile duct occlusion there is a rapid decrease in the plasma LCAT activity which is followed by an increase in the activity to normal values at a later time. 2--In the rat subjected to interruption of the enterohepatic circulation of bile salts by means of a sequestering agent there is an increase in the plasma LCAT activity. 3--In the rat subjected to a 48 hour fast there is an increase in the plasma LCAT activity. 4--In the rat subjected to a small dietary cholesterol supplement there is an increase in the plasma LCAT activity.