Sroczyński J, Wegiel A, Znamirowska D, Koczwara A
Med Pr. 1984;35(5):383-6.
In two groups of workers exposed to vibration and noise exceeding allowable standards within 3 to 30 years for over 4 hrs daily, the activity of creatine kinase-test enzyme for the diagnosis of muscular diseases and traumata was evaluated. Both in group I, composed of 74 workers aged 21-51 (38 on average) topically exposed to mechanical vibrations and noise, and in group II, composed of 45 workers aged 25-51 (37 on average), with topical or whole-body exposure to mechanical vibrations CPK was found to be significantly increased as compared to controls--26 workers carrying on medium (i.e. not very hard) work. In the group of 30 workers exposed to noise only, CPK values were comparable with the control group. CPK was increased irrespective of evident angioneurosis and duration of exposure. The obtained results indicate the advisability of applying the CPK activity investigation as an exposure test.
在两组每日暴露于超过允许标准的振动和噪声环境下3至30年、且每天暴露时间超过4小时的工人中，对用于诊断肌肉疾病和创伤的肌酸激酶测试酶的活性进行了评估。第一组由74名年龄在21至51岁（平均38岁）的工人组成，他们局部暴露于机械振动和噪声环境中；第二组由45名年龄在25至51岁（平均37岁）的工人组成，他们局部或全身暴露于机械振动环境中。结果发现，与对照组（26名从事中等强度工作的工人）相比，这两组工人的肌酸磷酸激酶（CPK）均显著升高。在仅暴露于噪声环境的30名工人组中，CPK值与对照组相当。无论是否存在明显的血管神经症以及暴露持续时间长短，CPK都会升高。所得结果表明，应用CPK活性检测作为暴露测试是可取的。
