Lin W S, Scrimshaw C, Kapoor M
Xenobiotica. 1984 Dec;14(12):893-902. doi: 10.3109/00498258409151488.
Liver homogenates from rats injected with 3-methylcholanthrene were employed for metabolism of benzo[a]pyrene (BP) and in assays of aryl hydrocarbon hydroxylase (AHH) activity in vitro. Sodium selenite inhibited AHH activity to a maximum of approximately 70%. It suppressed the overall metabolism of benzo[a]pyrene; a distinct reduction in the products was evident on h.p.l.c. analysis. Sodium thiosulphate also inhibited AHH activity by approximately 47%. Inclusion of S2O3(2-) and SeO3(2-), in combination, led to a cumulative inhibition of 87%. The mutagenicity of BP in the Salmonella auxotroph reversion system (Ames test) was enhanced by SeO3(2-) at concentrations below 0.2 mM. Above this level a significant antimutagenic effect was observed.
用注射了3-甲基胆蒽的大鼠肝脏匀浆进行苯并[a]芘（BP）的代谢及体外芳烃羟化酶（AHH）活性测定。亚硒酸钠对AHH活性的抑制作用最大可达约70%。它抑制了苯并[a]芘的整体代谢；高效液相色谱分析显示产物明显减少。硫代硫酸钠也使AHH活性抑制了约47%。同时加入S2O3(2-)和SeO3(2-)导致累积抑制率达87%。在沙门氏菌营养缺陷型回复突变系统（艾姆斯试验）中，浓度低于0.2 mM的SeO3(2-)可增强BP的致突变性。高于此水平则观察到显著的抗诱变作用。
