Neurath A R, Kent S B, Strick N
Virus Res. 1984;1(4):321-31. doi: 10.1016/0168-1702(84)90021-2.
Peptides corresponding to amino acid residues 48-65 and 69-79 of the major polypeptide component of hepatitis B surface antigen (HBsAg) were synthesized and conjugated to protein (bovine serum albumin and keyhole limpet hemocyanin) and fully synthetic (polyglutaraldehyde and cross-linked liposomes) carriers. The peptide-liposome conjugates appeared the most consistent in eliciting antibodies to HBsAg. Results of competition assays between each of the free synthetic peptides and HBsAg for antibodies suggested that the synthetic analogues and the corresponding segments on intact HBsAg are structurally closely related.
合成了与乙型肝炎表面抗原（HBsAg）主要多肽成分的氨基酸残基48 - 65和69 - 79相对应的肽，并将其与蛋白质（牛血清白蛋白和钥孔戚血蓝蛋白）以及完全合成的载体（聚戊二醛和交联脂质体）偶联。肽 - 脂质体偶联物在引发针对HBsAg的抗体方面表现出最一致的效果。每种游离合成肽与HBsAg之间针对抗体的竞争试验结果表明，合成类似物与完整HBsAg上的相应片段在结构上密切相关。
