Vandenburg M J, Evans S J, Kelly B J, Bradshaw F, Currie W J, Cooper W D
Br J Clin Pharmacol. 1984;18 Suppl 2(Suppl 2):189S-195S. doi: 10.1111/j.1365-2125.1984.tb02597.x.
Patients diagnosed as hypertensive have a high complaint rate, both on and off treatment and this has been postulated to be due to either their disease process, their being labelled as hypertensive, or to their treatment. Data from 6637 hypertensive patients being entered into clinical trials in general practice have been analysed to determine the relationship between the patient's age, sex, concurrent illnesses, concurrent medication, whether they were on antihypertensive treatment and the frequency of their reporting symptoms. The analysis was conducted using a multivariate technique. The frequency of reporting symptoms was greater in females than males. Those receiving antihypertensive therapy reported more symptoms than those who were not. This was notable with those receiving a beta-adrenoceptor blocker (47% of such patients complaining). Patients receiving concurrent medication were more likely to report a symptom than those not (48 compared to 37%). This was particularly noticeable if central nervous system-acting drugs were prescribed where the prevalence of symptoms was 52%. Patients already on antihypertensive treatment were more likely to be taking other medication for other conditions (37 vs 31%) than those not receiving antihypertensive treatment. Females were more likely to be taking other tablets than males (38 compared to 30%). The only symptoms which were less prevalent in those receiving treatment were headache, dizziness and breathlessness. All other symptoms were increased or unchanged in patients on antihypertensive therapy. This study indicates that present treatment for hypertension produces a high complaint rate from patients and that, when patients so complain, the possibility of their symptoms being due to their concurrent medication should be considered.
被诊断为高血压的患者，无论在治疗期间还是治疗之外，投诉率都很高。据推测，这可能是由于他们的疾病进程、被贴上高血压的标签或者治疗本身。对6637名正在参与全科医疗临床试验的高血压患者的数据进行了分析，以确定患者的年龄、性别、并发疾病、同时服用的药物、是否接受抗高血压治疗以及他们报告症状的频率之间的关系。分析采用了多变量技术。女性报告症状的频率高于男性。接受抗高血压治疗的患者比未接受治疗的患者报告的症状更多。接受β-肾上腺素受体阻滞剂治疗的患者尤其明显（47%的此类患者有症状投诉）。正在同时服用其他药物的患者比未服用的患者更有可能报告症状（分别为48%和37%）。如果开了中枢神经系统作用药物，症状发生率为52%，这种情况尤其明显。已经接受抗高血压治疗的患者比未接受抗高血压治疗的患者更有可能因其他病症服用其他药物（分别为37%和31%）。女性比男性更有可能服用其他片剂（分别为38%和30%）。接受治疗的患者中发生率较低的症状只有头痛、头晕和呼吸急促。接受抗高血压治疗的患者的所有其他症状都有所增加或没有变化。这项研究表明，目前的高血压治疗导致患者投诉率很高，并且当患者提出投诉时，应考虑其症状可能是由于同时服用的药物所致。
