甲状腺疾病中的心脏功能与辅酶Q10

Cardiac performance and coenzyme Q10 in thyroid disorders.

作者信息

Suzuki H, Naitoh T, Kuniyoshi S, Banba N, Kuroda H, Suzuki Y, Hiraiwa M, Yamazaki N, Ishikawa M, Hashigami Y

出版信息

Endocrinol Jpn. 1984 Dec;31(6):755-61. doi: 10.1507/endocrj1954.31.755.

DOI:10.1507/endocrj1954.31.755

Abstract

To investigate the relationship between serum levels of Coenzyme Q10 and cardiac performance in thyroid disorders, we studied the cardiac performance and assessed serum levels of thyroid hormones and Coenzyme Q10 in 20 patients with hyperthyroidism, 5 patients with hypothyroidism and 10 normal subjects. A significant inverse correlation between thyroid hormones and Coenzyme Q10 levels was found by performing partial correlation analysis. Because low serum levels of Coenzyme Q10 were found in thyrotoxic patients and congestive heart failure may occur as a result of severe hyperthyroidism, 120 mg of Coenzyme Q10 was administered daily for one week to 12 hyperthyroid patients and the change in cardiac performance was assessed. Further augmentation of cardiac performance was found in hyperthyroid hearts, which were already augmented, after the administration of Coenzyme Q10. It appears, therefore, that the Coenzyme Q10 dose actually has a therapeutic value for congestive heart failure induced by severe thyrotoxicosis.

摘要

为了研究甲状腺疾病患者血清辅酶Q10水平与心脏功能之间的关系，我们对20例甲状腺功能亢进患者、5例甲状腺功能减退患者和10名正常受试者的心脏功能进行了研究，并评估了血清甲状腺激素和辅酶Q10水平。通过进行偏相关分析，发现甲状腺激素与辅酶Q10水平之间存在显著的负相关。由于甲状腺毒症患者血清辅酶Q10水平较低，且严重甲状腺功能亢进可能导致充血性心力衰竭，因此对12例甲状腺功能亢进患者每天给予120毫克辅酶Q10，持续一周，并评估心脏功能的变化。在给予辅酶Q10后，已增强的甲状腺功能亢进心脏的心脏功能进一步增强。因此，辅酶Q10剂量似乎对严重甲状腺毒症引起的充血性心力衰竭具有治疗价值。