Suzuki H, Kasai K, Shimoda S I
J Endocrinol Invest. 1981 Jul-Sep;4(3):289-94. doi: 10.1007/BF03349446.
Fifteen patients with thyrotoxicosis, 8 patients with primary hypothyroidism and 15 normal subjects were studied to assess the correlation between systolic time intervals and serum levels of thyroid hormones. In hypothyroid patients, prolongation of PEPc (corrected pre-ejection period), shortening of LVETc (corrected left ventricular ejection time) and low values of LVET/PEP ratio and cardiac output were improved after restoration of thyroid function. In thyrotoxic patients, shortening of PEPc, high values of LVET/PEP ratio and cardiac output were normalized after correction of thyroid function. As contrasted with these observations, in 5 severely thyrotoxic patients, low values of LVET/PEP ratio and cardiac output for thyrotoxicosis were observed; these were not significantly decreased after antithyroid drug treatment, but appeared to have a tendency to increase. Performing polynomial regression analysis, a significant parabolic correlation was found between LVET/PEP and serum T4 or T3 (p less than 0.0001). From these results, it might be concluded that large amounts of thyroid hormones suppress cardiac performance.
对15例甲状腺毒症患者、8例原发性甲状腺功能减退患者和15名正常受试者进行了研究，以评估收缩期时间间期与甲状腺激素血清水平之间的相关性。在甲状腺功能减退患者中，甲状腺功能恢复后，PEPc（校正射血前期）延长、LVETc（校正左心室射血时间）缩短、LVET/PEP比值降低和心输出量降低的情况得到改善。在甲状腺毒症患者中，甲状腺功能纠正后，PEPc缩短、LVET/PEP比值升高和心输出量恢复正常。与这些观察结果形成对比的是，在5例重度甲状腺毒症患者中，观察到甲状腺毒症患者的LVET/PEP比值和心输出量较低；抗甲状腺药物治疗后这些指标没有明显下降，但似乎有升高的趋势。进行多项式回归分析发现，LVET/PEP与血清T4或T3之间存在显著的抛物线相关性（p小于0.0001）。从这些结果可以得出结论，大量甲状腺激素会抑制心脏功能。
