Sørlie D, Myhre K
Scand J Clin Lab Invest. 1978 Apr;38(2):171-9. doi: 10.3109/00365517809156086.
Lower leg blood flow was measured at rest and both during and after graduated bicycle exercise in five healthy men and in seventeen patients suffering from various degrees of obliterating arteriosclerosis of the lower limbs. A thermodilution technique was used for flow determinations. The subject exercised in the sitting position and the work load was increased stepwise from a starting load of 100 kpm/min (100 kpm/min load increment every second minute until exhaustion). Three flow phases were depicted during and after the exercise: the aerobic phase, the phase of relative ischaemia and a postexercise phase. During exercise, lower leg blood flow increased approximately twenty times in healthy subjects, while in the arteriosclerotic subjects there was a two-fold to ten-fold increase in flow. In patients with serious distal and proximal stenoses a proximal steal phenomenon was demonstrated during submaximal and maximal exercise. A close correlation was found between maximum individual work load capacity and maximum lower leg blood flow (r = 0.71, P less than 0.001). In the patient group lower leg blood flow at a certain work load was 45% (P less than 0.001) higher in the sitting than in the supine position.
对5名健康男性和17名患有不同程度下肢闭塞性动脉硬化的患者，在静息状态下以及在分级自行车运动期间和运动后测量小腿血流量。采用热稀释技术测定血流量。受试者坐在座位上进行运动，工作负荷从起始负荷100 kpm/min开始逐步增加（每隔一分钟增加100 kpm/min负荷直至疲劳）。运动期间和运动后描绘出三个血流阶段：有氧阶段、相对缺血阶段和运动后阶段。运动期间，健康受试者的小腿血流量增加约20倍，而动脉硬化受试者的血流量增加2至10倍。在患有严重远端和近端狭窄的患者中，在次最大和最大运动期间出现近端盗血现象。发现个体最大工作负荷能力与最大小腿血流量之间存在密切相关性（r = 0.71，P < 0.001）。在患者组中，在一定工作负荷下，坐位时的小腿血流量比仰卧位时高45%（P < 0.001）。
