Sørlie D, Myhre K
Scand J Clin Lab Invest. 1978 May;38(3):217-22.
Mechanisms for increased claudication distance following physical training were studied in ten patients with peripheral arterial insufficiency. The exercise capacity on a bicycle ergometer increased by an average of 26% after 3--4 months of training (P less than 0.05). Neither maximum lower leg blood flow during the exercise test nor oxygen uptake at exhaustion changed significantly after training (-8% and +5%, respectively), whereas popliteal-venous O2-saturation was lower at exhaustion after the training than before (8.5 +/- 3.2 and 11.4 +/- 4.6, respectively, P less than 0.05). Anaerobic glycolysis, as evidenced by the lactate release, was also lowered after the training (P less than 0.05). In conclusion, the present study shows that the increased exercise capacity following physical training in claudicants is associated with an increased local aerobic working capacity despite a virtually unchanged blood flow. This increased aerobic exercise capacity might partly be explained by an increased O2 extraction in the lower leg during exercise.
对10例外周动脉供血不足患者进行了体育锻炼后跛行距离增加机制的研究。经过3 - 4个月的训练，自行车测力计上的运动能力平均提高了26%（P < 0.05）。训练后，运动试验期间的最大小腿血流量和力竭时的摄氧量均无显著变化（分别下降8%和增加5%），而训练后力竭时腘静脉血氧饱和度低于训练前（分别为8.5±3.2和11.4±4.6，P < 0.05）。训练后，如乳酸释放所示的无氧糖酵解也降低了（P < 0.05）。总之，本研究表明，尽管血流量几乎没有变化，但体育锻炼后跛行者运动能力的提高与局部有氧工作能力的增加有关。这种有氧运动能力的提高可能部分是由于运动期间小腿的氧摄取增加所致。
