来自外周血的人单核白细胞的吞噬作用相关趋化性对抗微管蛋白不敏感。

The phagocytosis-associated chemotaxis of human mononuclear leucocytes from peripheral blood is not antitubulin-sensitive.

作者信息

Rydgren L, Norberg B, Svensson B, Simmingskoeld G

出版信息

Scand J Immunol. 1978 Mar;7(3):251-7. doi: 10.1111/j.1365-3083.1978.tb00452.x.

DOI:10.1111/j.1365-3083.1978.tb00452.x

Abstract

Lymphoprep-isolated and glass-adherent mononuclear leucocytes (L-MNs) from the peripheral blood of healthy donors appeared to display directional locomotion towards sparsely distributed yeast cells during continuous observation in coverslip preparations and during observations by means of time-lapse filming in Rose chambers. The phagocytosis-associated L-MN chemotaxis was not inhibited by antitubulin concentrations which were antichemotactic thesis that a direct antitubulin-insensitive chemotaxis exists in L-MNs, besides the antitubulin-inhibited L-MN chemoataxis reported in a previous study.

摘要

在盖玻片制备物的连续观察过程中以及在罗斯小室中通过延时拍摄进行观察时，从健康供体的外周血中通过淋巴细胞分离液分离并经玻璃黏附的单核白细胞（L-MNs）似乎朝着稀疏分布的酵母细胞呈现出定向运动。吞噬作用相关的L-MN趋化性不受抗微管蛋白浓度的抑制，而抗微管蛋白浓度具有抗趋化作用。这表明，除了先前研究中报道的抗微管蛋白抑制的L-MN趋化作用外，L-MNs中还存在一种直接的抗微管蛋白不敏感的趋化作用。