亚急性硬化性全脑炎中的麻疹病毒基因表达
Measles virus gene expression in subacute sclerosing panencephalitis.
作者信息
Baczko K, Carter M J, Billeter M, ter Meulen V
出版信息
Virus Res. 1984 Oct;1(7):585-95. doi: 10.1016/0168-1702(84)90015-7.
Abstract
RNA was extracted from the diseased brain of a case of human subacute sclerosing panencephalitis (SSPE) and analysed for the expression of measles-specific RNA. Measles virus-specific mRNAs were present, but the amount of matrix (M) protein mRNA was greatly reduced in comparison to lytically infected cells and phospho- (P) protein mRNA was hardly detectable whereas the level of the corresponding intermediate-sized (is-) RNA was greatly increased. RNA obtained from the human brain was also translated in vitro and measles virus nucleocapsid and P protein was produced. However, in marked contrast to control reactions M protein was not detected in the products formed by translation in vitro. These results indicate an impaired measles virus M protein mRNA synthesis in infected brain tissue.
摘要
从一名人类亚急性硬化性全脑炎（SSPE）患者的病变脑组织中提取RNA，并分析麻疹特异性RNA的表达情况。存在麻疹病毒特异性mRNA，但与溶细胞感染的细胞相比，基质（M）蛋白mRNA的量大幅减少，磷酸化（P）蛋白mRNA几乎检测不到，而相应的中等大小（is-）RNA水平大幅增加。从人脑中获得的RNA也在体外进行翻译，并产生了麻疹病毒核衣壳和P蛋白。然而，与对照反应形成鲜明对比的是，在体外翻译形成的产物中未检测到M蛋白。这些结果表明，感染的脑组织中麻疹病毒M蛋白mRNA合成受损。
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