用单克隆抗体通过免疫荧光法在亚急性硬化性全脑炎患者大脑中检测麻疹病毒基质蛋白。
Measles virus matrix protein detected by immune fluorescence with monoclonal antibodies in the brain of patients with subacute sclerosing panencephalitis.
作者信息
Norrby E, Kristensson K, Brzosko W J, Kapsenberg J G
出版信息
J Virol. 1985 Oct;56(1):337-40. doi: 10.1128/JVI.56.1.337-340.1985.
Abstract
Brain materials from four cases of subacute sclerosing panencephalitis were examined by immune fluorescence with monoclonal antibodies against five structural components of measles virus. All five antigens including the matrix component were present in the brain tissues of all cases. A defective Vero cell-associated virus isolate from one of the cases produced all of the structural components except the matrix protein.
摘要
用抗麻疹病毒五种结构成分的单克隆抗体，通过免疫荧光法对4例亚急性硬化性全脑炎患者的脑材料进行了检测。包括基质成分在内的所有五种抗原均在所有病例的脑组织中出现。从其中1例患者分离出的一株与Vero细胞相关的缺陷病毒，除基质蛋白外，能产生所有结构成分。
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