Menge A C, Mangione C M, Dietrich J W, Black C S
Arch Androl. 1984;12 Suppl:83-8.
Human sera with elevated titers of antisperm antibodies reduced the capacity of human sperm to penetrate zona-free hamster ova. Of 111 sera examined, 33 (30%) reduced the mean percentage of ova penetrated to less than 52%, which was significantly different from the overall control mean (75%). Three sera reduced the penetration of ova to 7% or less. The inhibitory effect of these three sera was still present in their respective Fab preparations. An analysis of antibody effects revealed that the presence of sperm-immobilizing antibodies had a significantly greater influence on sperm penetration capacity than agglutinating antibodies. Sperm motility per se appeared to be unaffected by the different sera. Sperm treated with cervical mucus (CM) samples generally exhibited a lesser degree of ova penetration than did sperm treated with serum or medium alone. Among CM groups, however, samples containing detectable sperm-immobilizing antibody activity or samples from women with circulating antisperm antibody caused significant reductions in sperm penetration capacity.
抗精子抗体滴度升高的人血清降低了人类精子穿透去透明带仓鼠卵的能力。在检测的111份血清中，33份（30%）将卵穿透的平均百分比降低至52%以下，这与总体对照平均值（75%）有显著差异。三份血清将卵的穿透率降低至7%或更低。这三份血清的抑制作用在其各自的Fab制剂中仍然存在。抗体效应分析表明，精子固定抗体的存在对精子穿透能力的影响明显大于凝集抗体。精子活力本身似乎不受不同血清的影响。用宫颈黏液（CM）样本处理的精子通常比仅用血清或培养基处理的精子表现出更低的卵穿透程度。然而，在CM组中，含有可检测到的精子固定抗体活性的样本或来自有循环抗精子抗体女性的样本导致精子穿透能力显著降低。
