Newsome W H, Iverson F, Ryan J J, Lau P Y, McLeod H A
Food Addit Contam. 1984 Jan-Mar;1(1):3-9. doi: 10.1080/02652038409385816.
Broiler chickens were raised on commercial wood shavings containing 134 p.p.m. pentachlorophenol and on control litter consisting of corn-cob chips. Initial analysis of the wood-shaving litter showed the presence of hepta-, octa- and nonachlorinated diphenyl ethers, octa- and nonachlorinated 2-phenoxyphenols, and hepta- and octachlorinated dibenzodioxins. Analysis of liver, fat, and muscle tissue after nine weeks indicated the assimilation of these compounds with pentachlorophenol being present in the highest concentration. Chlorinated diphenyl ethers were detectable only in fat, while octa- and nonachlorinated 2-phenoxyphenols were found in all three tissues examined. While liver and fat contained hepta- and octachlorinated dibenzodioxins, no hexachlorinated congener was detected nor were significant amounts of dioxin found in muscle tissue. Although gross pathological examination of the birds did not indicate abnormalities, a mixed type of hepatic enzyme induction was observed in those birds raised on wood shavings.
肉鸡分别饲养在含有134 ppm五氯苯酚的商用刨花上和由玉米芯碎片组成的对照垫料上。对刨花垫料的初步分析表明存在七氯、八氯和九氯二苯醚、八氯和九氯2-苯氧基苯酚以及七氯和八氯二苯并二恶英。九周后对肝脏、脂肪和肌肉组织的分析表明这些化合物被同化，其中五氯苯酚的浓度最高。氯化二苯醚仅在脂肪中可检测到，而八氯和九氯2-苯氧基苯酚在所有三个检测组织中均有发现。虽然肝脏和脂肪中含有七氯和八氯二苯并二恶英，但未检测到六氯同类物，肌肉组织中也未发现大量二恶英。尽管对这些鸡的大体病理检查未显示异常，但在饲养在刨花上的鸡中观察到了混合型肝酶诱导现象。
