胍乙啶交感神经切除术不能阻止进食引起的棕色脂肪重量增加或耗氧量增加。
Guanethidine sympathectomy does not prevent meal-induced increases in the weight or oxygen consumption of brown fat.
作者信息
Tordoff M G, Glick Z, Butcher L L, Novin D
出版信息
Physiol Behav. 1984 Dec;33(6):975-9. doi: 10.1016/0031-9384(84)90239-7.
PMID:6537529
Abstract
The interscapular brown adipose tissue (BAT) of adult rats that were neonatally sympathectomized with guanethidine (GUA) consumed less oxygen but weighed the same as BAT from intact controls. In response to a 2-hr mixed-constituent meal, BAT from sympathectomized and control rats showed similar increases in oxygen uptake and weight. These data suggest that some functions of BAT can be maintained even without sympathetic stimulation.
摘要
新生期用胍乙啶（GUA）进行交感神经切除术的成年大鼠肩胛间棕色脂肪组织（BAT）耗氧量减少，但重量与完整对照组的BAT相同。对2小时混合成分餐的反应中，交感神经切除大鼠和对照大鼠的BAT在摄氧量和重量上表现出相似的增加。这些数据表明，即使没有交感神经刺激，BAT的某些功能也可以维持。
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