Morrissey R E
Food Chem Toxicol. 1984 Jun;22(6):453-7. doi: 10.1016/0278-6915(84)90328-4.
Vomitoxin (deoxynivalenol), a tricothecene mycotoxin produced by Fusarium species, has been detected in corn, wheat and other cereal grains intended for consumption by man and by animals used for food. The teratogenic potential of vomitoxin administered in the diet was studied by feeding a vomitoxin-containing certified rat feed ad lib. to groups of Fischer 344 rats during the entire course of pregnancy. The vomitoxin was added to the diet at a level of 0.0, 0.5, 2.0 or 5.0 ppm. There were no overt signs of toxicity in the dams, and no statistically significant differences in feed consumption at any level compared to the control group. Dams in the two groups receiving the highest levels of vomitoxin tended to weigh less at term than other females, and after removal of the pups and uterus their carcass weights were significantly lower than those in the control group. Term foetuses were examined by standard teratological techniques. Male and female pup weights were unaffected by the maternal treatment. Vomitoxin had no statistically significant adverse effects on the incidence of gross, skeletal or visceral abnormalities. Neither dams nor pups showed any significant histopathological changes.
呕吐毒素（脱氧雪腐镰刀菌烯醇）是由镰刀菌属产生的一种单端孢霉烯族真菌毒素，已在供人类食用的玉米、小麦及其他谷物以及用作食物的动物饲料中被检测到。通过在整个孕期随意投喂含呕吐毒素的经认证的大鼠饲料，研究了饮食中摄入呕吐毒素的致畸潜力。将呕吐毒素以0.0、0.5、2.0或5.0 ppm的水平添加到饲料中。母鼠没有明显的中毒迹象，与对照组相比，任何水平下的饲料消耗量均无统计学显著差异。接受最高呕吐毒素水平的两组母鼠在足月时体重往往比其他母鼠轻，在取出幼崽和子宫后，它们的胴体重量显著低于对照组。通过标准的致畸学技术检查足月胎儿。母鼠的处理对雄性和雌性幼崽的体重没有影响。呕吐毒素对大体、骨骼或内脏异常的发生率没有统计学显著的不良影响。母鼠和幼崽均未表现出任何明显的组织病理学变化。
