Morrissey R E, Vesonder R F
Appl Environ Microbiol. 1985 May;49(5):1062-6. doi: 10.1128/aem.49.5.1062-1066.1985.
A diet containing 20 ppm (micrograms/g) of purified deoxynivalenol (DON) was fed to male and female Sprague-Dawley rats for 60 and 15 days, respectively, before breeding. Rats consuming feed amended with DON throughout pregnancy and lactation showed no clinical signs of toxicity, nor did the control or pair-fed control groups. Male rats in the DON treatment group showed no feed refusal but were less efficient than males in control groups in converting feed into body mass. Feed refusal in female rats varied with stage of pregnancy. Before breeding, overall feed consumption was similar in all groups, but in the DON treatment group there was significant feed refusal for the first 2 days. Feed conversion efficiency was reduced in the DON treatment group. Pregnant and lactating rats fed DON-treated feed ate 6% less than did control rats fed solvent-treated feed. Although pair-fed control rats ate 14 to 21% less than rats in the DON treatment group, their body weights were greater than those of the DON group rats throughout most of the feeding trials, indicating that DON has a toxic effect. Only 50% of the matings between DON group rats resulted in pregnancy, compared with 80% in the control groups. There were no differences detected among groups in ratio of male to female pups, survival rate, or average litter number and weight. Pup weight gains in all groups were comparable through postnatal day 14.(ABSTRACT TRUNCATED AT 250 WORDS)
在繁殖前，分别给雄性和雌性斯普拉格-道利大鼠喂食含20 ppm（微克/克）纯化脱氧雪腐镰刀菌烯醇（DON）的饲料60天和15天。在整个怀孕和哺乳期食用添加了DON的饲料的大鼠没有出现毒性的临床症状，对照组和配对喂养对照组的大鼠也没有。DON处理组的雄性大鼠没有出现拒食情况，但在将饲料转化为体重方面比对照组的雄性大鼠效率低。雌性大鼠的拒食情况随怀孕阶段而变化。在繁殖前，所有组的总体饲料消耗量相似，但在DON处理组中，前2天有明显的拒食现象。DON处理组的饲料转化效率降低。喂食DON处理饲料的怀孕和哺乳期大鼠比喂食溶剂处理饲料的对照大鼠少吃6%。尽管配对喂养的对照大鼠比DON处理组的大鼠少吃14%至21%，但在大多数喂养试验中，它们的体重都比DON组大鼠的体重大，这表明DON具有毒性作用。DON组大鼠之间只有50%的交配导致怀孕，而对照组为80%。各组之间在雌雄幼崽比例、存活率或平均窝仔数和体重方面没有检测到差异。在出生后第14天之前，所有组的幼崽体重增加情况相当。（摘要截短至250字）
