Meerson F Z, Saulia A I
Kardiologiia. 1984 Jun;24(6):19-23.
Rats adapted to exercise (daily swimming for one hour over 30 days) and control animals were subjected to emotional-painful stress (EPS) according to the pattern of anxiety neurosis. It has been established that EPS decreases the amplitude as well as the rate of contractions and relaxations of the isolated papillary muscles of animals by 2-3 times and also reduces the resistance of the contractile function of the myocardium to the excess of Na+ and H+ ions, ousting Ca2+ from the sites of its binding in the sarcolemma. Adaptation to exercise exerts an opposite effect. The preliminary adaptation of animals prior to EPS prevents or limits the stress-related depression of the contractility of the myocardium and the diminution of its resistance to the factors replacing Ca2+. The preliminary adaptation to exercise may be used for preventing stress-related disorders of cardiac contractility.
使大鼠适应运动（30天内每天游泳1小时），并根据焦虑神经症模式对对照动物施加情感痛苦应激（EPS）。已经确定，EPS可使动物离体乳头肌的收缩和舒张幅度以及速率降低2至3倍，还会降低心肌收缩功能对过量Na+和H+离子的耐受性，将Ca2+从其在肌膜上的结合位点排挤出去。适应运动则产生相反的效果。在EPS之前对动物进行预先适应可预防或限制与应激相关的心肌收缩力下降及其对替代Ca2+的因素的耐受性降低。运动的预先适应可用于预防与应激相关的心脏收缩功能障碍。
