Xiao X S, Veldhuis H D, Van Ree J M
Neuropeptides. 1984 May;4(3):237-45. doi: 10.1016/0143-4179(84)90104-5.
The interaction between peptides related to neurohypophyseal hormones and brain dopaminergic systems was studied by investigating in rats the effect of these peptides on behavioral changes induced by graded doses of the specific dopamine agonist apomorphine. Low doses of this drug induce hypoactivity of the animals, while higher doses result in hyperactivity and stereotyped sniffing. Desglycinamide9[Arg8]vasopressin (DG-AVP), prolyl-leucyl-glycinamide (PLG) and oxytocin did not interfere with the behavioral responses induced by the higher doses of apomorphine. Peptide treatment made the rats more sensitive to apomorphine with respect to the drug induced hypoactivity. PLG and especially DG-AVP were more effective than oxytocin. It is concluded that these peptides may have a selective action on distinct dopaminergic receptor systems in the brain, that are presumably located presynaptically in the nucleus accumbens area.
通过研究大鼠中与神经垂体激素相关的肽对特定多巴胺激动剂阿扑吗啡不同剂量诱导的行为变化的影响，来研究这些肽与脑多巴胺能系统之间的相互作用。低剂量的这种药物会诱导动物活动减少，而高剂量则导致活动过度和刻板嗅闻。去甘氨酰胺9[精氨酸8]加压素（DG-AVP）、脯氨酰-亮氨酰-甘氨酰胺（PLG）和催产素不会干扰高剂量阿扑吗啡诱导的行为反应。肽处理使大鼠对阿扑吗啡诱导的活动减少更敏感。PLG，尤其是DG-AVP比催产素更有效。得出的结论是，这些肽可能对脑中不同的多巴胺能受体系统具有选择性作用，这些系统可能位于伏隔核区域的突触前。
