神经垂体激素对海洛因自我给药的调节作用。

Modulation of heroin self-administration by neurohypophyseal principles.

作者信息

Van Ree J M, De Wied D

出版信息

Eur J Pharmacol. 1977 May 15;43(2):199-202. doi: 10.1016/0014-2999(77)90132-7.

Abstract

Neuropeptides related to hypothalomic-neurohypophyseal hormones affect intravenous heroin self-administration behavior in rats. Desglycinamide9, arginine8-vasopressin and pressinamide reduced, while oxytocin and its C-terminal tripeptide, prolyl-leucyl-glycinamide facilitated this behavior. The effectiveness of the vasopressin analogue appeared to be of a long term nature. The data indicate a modulating effect of these principles on the reinforcing efficacy of heroin.

摘要

与下丘脑-神经垂体激素相关的神经肽影响大鼠静脉注射海洛因的自我给药行为。去甘氨酰胺9、精氨酸8-加压素和加压素酰胺可减少这种行为，而催产素及其C末端三肽脯氨酰-亮氨酰-甘氨酰胺则促进这种行为。加压素类似物的作用似乎具有长期性。这些数据表明这些物质对海洛因的强化效力具有调节作用。