Kanta J, Bartos F
Acta Hepatogastroenterol (Stuttg). 1978 Oct;25(5):350-2.
Elastin fibers formation was previously found to be an important feature of advanced human liver cirrhosis. Now it has been shown that chronic carbon tetrachloride administration to rats can be used to simulate this condition experimentally. Elastin fibers are found in the septa of connective tissue surrounding parenchymal nodules. Elastin content in liver measured as hydroxyproline insoluble in 0.1 N NaOH is increased about 3 times after a 4 month carbon tetrachloride treatment.
弹性纤维形成先前被发现是晚期人类肝硬化的一个重要特征。现在已经表明，对大鼠长期给予四氯化碳可用于在实验中模拟这种情况。弹性纤维存在于实质结节周围结缔组织的间隔中。以不溶于0.1N氢氧化钠的羟脯氨酸来衡量，在经过4个月的四氯化碳处理后，肝脏中的弹性蛋白含量增加了约3倍。
