对阿尔茨海默型老年痴呆症患者“缠结”富集部分的超微结构研究。
Ultrastructural study of enriched fractions of "tangles" from human patients with senile dementia of the Alzheimer type.
作者信息
Brion J P, Couck A M, Flament-Durand J
出版信息
Acta Neuropathol. 1984;64(2):148-52. doi: 10.1007/BF00695578.
PMID:6540969
Abstract
Enriched fractions of "tangles" obtained from cases of Alzheimer's disease have been observed by negative staining and platinum: iridium shadowing, and also after treatment with sodium dodecyl sulfate and urea. Abnormal filaments with a 80-nm periodic constriction exhibited a substructure consisting of six protofilaments. They also showed a periodic right-handed twist. Some fibrils with a 160-nm periodic constriction were made up of four protofilaments. These features are discussed in view of known fibrous protein models, especially neurofilaments.
摘要
通过负染色和铂
铱投影观察了从阿尔茨海默病病例中获得的“缠结”富集部分，在用十二烷基硫酸钠和尿素处理后也进行了观察。具有80纳米周期性收缩的异常细丝呈现出由六个原纤维组成的亚结构。它们还表现出周期性的右手扭曲。一些具有160纳米周期性收缩的纤维由四个原纤维组成。鉴于已知的纤维状蛋白质模型，特别是神经丝，对这些特征进行了讨论。
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