Dubuisson L, Vonnahme F J, Balabaud C, Grün M
Exp Pathol. 1984;26(1):49-58. doi: 10.1016/s0232-1513(84)80068-7.
The development of preneoplastic and neoplastic alterations in the urinary tract was investigated by light and scanning electron microscopy in rats after portacaval anastomosis. The changes consisted of slight hyperplasia to papillary hyperplasia after 24 weeks. Carcinomas were present in all animals after 52 weeks. Surface characteristics can be correlated with the sequence of changes in urothelial cells. Short uniform microvilli appear in moderate hyperplasia and a cobblestone formation of the cells is typical of papillary hyperplasia. In transitional cell carcinomas the cells varied in shape and size and they were densely covered with pleomorphic microvilli. Although the cause of tumour induction after portacaval anastomosis is not clearly understood, possible mechanisms are discussed.
通过光镜和扫描电子显微镜研究了大鼠门腔静脉吻合术后泌尿道癌前病变和肿瘤性病变的发展。变化包括24周后从轻度增生到乳头样增生。52周后所有动物均出现癌。表面特征与尿路上皮细胞的变化顺序相关。短而均匀的微绒毛出现在中度增生中，细胞呈鹅卵石样排列是乳头样增生的典型表现。在移行细胞癌中，细胞形状和大小各异，表面密布多形性微绒毛。虽然门腔静脉吻合术后诱发肿瘤的原因尚不清楚，但文中讨论了可能的机制。
