c-fos原癌基因转移后F9畸胎瘤干细胞的分化
Differentiation of F9 teratocarcinoma stem cells after transfer of c-fos proto-oncogenes.
作者信息
Müller R, Wagner E F
出版信息
Nature. 1984;311(5985):438-42. doi: 10.1038/311438a0.
DOI:10.1038/311438a0
PMID:6541297
Abstract
Transfer of mouse or human c-fos proto-oncogenes into F9 teratocarcinoma stem cells results in expression of c-fos mRNA and protein. This is accompanied by the appearance of morphologically altered cells which express several specific markers characteristic of differentiated cells, suggesting that c-fos plays a role in cellular differentiation.
摘要
将小鼠或人类的c-fos原癌基因导入F9畸胎瘤干细胞中，会导致c-fos信使核糖核酸（mRNA）和蛋白质的表达。与此同时，会出现形态改变的细胞，这些细胞表达几种分化细胞特有的特定标志物，这表明c-fos在细胞分化中发挥作用。
Zotero 插件