Johnson K I, Fenzl E, Hein B
Arzneimittelforschung. 1984;34(6):734-6.
This study was designed to show if therapeutic doses of cimetidine (Tagamet 400 Oblong-Filmtabletten; 400 mg b.i.d. and 400 mg t.i.d.) influence the elimination of alcohol. Following controlled alcohol doses to eight healthy volunteers without cimetidine and after three days cimetidine in the two dosage regimens, blood alcohol concentrations were determined and the degree of intoxication was recorded subjectively on a 100 mm scale. Statistical evaluation showed that the elimination and effects of the alcohol were similar on all three study days. One can conclude that, under these study conditions, cimetidine had no effect on the alcohol metabolism and blood concentration. Correlation between blood alcohol levels and degree of intoxication showed a significant linear relationship.
本研究旨在表明西咪替丁（泰胃美400毫克长效薄膜片；每日两次，每次400毫克和每日三次，每次400毫克）的治疗剂量是否会影响酒精的消除。在给八名未服用西咪替丁的健康志愿者服用受控剂量的酒精后，以及在三天内以两种给药方案服用西咪替丁后，测定血液酒精浓度，并在100毫米的量表上主观记录中毒程度。统计评估表明，在所有三个研究日，酒精的消除和效果相似。可以得出结论，在这些研究条件下，西咪替丁对酒精代谢和血液浓度没有影响。血液酒精水平与中毒程度之间的相关性显示出显著的线性关系。
