H2受体拮抗剂对日本志愿者乙醇代谢的影响。
Effects of H2-receptor antagonists on ethanol metabolism in Japanese volunteers.
作者信息
Tanaka E, Nakamura K
机构信息
Institute of Community Medicine, University of Tsukuba, Ibaraki-ken, Japan.
出版信息
Br J Clin Pharmacol. 1988 Jul;26(1):96-9. doi: 10.1111/j.1365-2125.1988.tb03370.x.
Abstract
The effects of H2-receptor antagonists (cimetidine, ranitidine, and famotidine) on ethanol metabolism were investigated. Neither in aldehyde dehydrogenase (ALDH)-1 deficient subjects nor in those with normal ALDH-1, did the three H2-receptor antagonists and placebo differ in their effects on the pharmacokinetic parameters of ethanol (i.e. peak time (tmax), metabolic rate (k0), peak serum concentration (Cmax), volume of distribution (V) and area under the concentration-time curve (AUC). The AUC of acetaldehyde was slightly but significantly (P less than 0.05) larger only after treatment with cimetidine. Cmax and tmax of acetaldehyde were unchanged.
摘要
研究了H2受体拮抗剂（西咪替丁、雷尼替丁和法莫替丁）对乙醇代谢的影响。在醛脱氢酶（ALDH）-1缺乏的受试者和ALDH-1正常的受试者中，三种H2受体拮抗剂和安慰剂对乙醇药代动力学参数（即达峰时间（tmax）、代谢率（k0）、血清峰值浓度（Cmax）、分布容积（V）和浓度-时间曲线下面积（AUC））的影响均无差异。仅在使用西咪替丁治疗后，乙醛的AUC略有增加但差异显著（P<0.05）。乙醛的Cmax和tmax未发生变化。
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