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雌二醇和孕酮抑制由2-脱氧-D-葡萄糖诱导的进食。

Estradiol and progesterone suppress feeding induced by 2-deoxy-D-glucose.

作者信息

McDermott L J, Jorgensen D E, Byers D J

出版信息

Physiol Behav. 1984 May;32(5):731-6. doi: 10.1016/0031-9384(84)90186-0.

DOI:10.1016/0031-9384(84)90186-0
PMID:6541795
Abstract

The feeding response to 2-deoxy-d-glucose (2DG) was measured in gonadally intact females (NORM) during estrus (EST) or diestrus (DIES) and in ovariectomized (OVEX) rats following injections of estradiol benzoate and progesterone (HORM) or oil (OIL). In both groups the response to 2DG under conditions of EST or HORM was significantly suppressed relative to DIES or OIL. The suppressant effect of hormones on 2DG feeding was not accounted for by the suppressant effects of ovarian hormones on ad lib feeding or a function of the body weight of the subject. The results are discussed in the context of ovarian hormonal effects on glucostatic control of feeding.

摘要

在发情期(EST)或间情期(DIES)对性腺完整的雌性(NORM)以及在注射苯甲酸雌二醇和孕酮(HORM)或油(OIL)后的去卵巢(OVEX)大鼠中测量了对2-脱氧-D-葡萄糖(2DG)的摄食反应。在两组中,相对于DIES或OIL,在EST或HORM条件下对2DG的反应均被显著抑制。激素对2DG摄食的抑制作用不能用卵巢激素对随意摄食的抑制作用或受试者体重的函数来解释。本文在卵巢激素对摄食的糖稳态控制的影响背景下讨论了这些结果。

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