Bodnar R J, Romero M T, Kest B, Stone E A
Psychopharmacology (Berl). 1987;91(2):207-8. doi: 10.1007/BF00217063.
Acute, but not chronic, antidepressant treatment potentiates the analgesic responses following cold-water swims. The present study evaluated the effects of acute (10 mg/kg) and chronic (10 mg/kg, twice daily over 7 days) pretreatment with desipramine (DMI) upon the analgesic response following 2-deoxy-D-glucose (2DG) in rats as measured by the jump test. Acute, but not chronic, DMI pretreatment significantly reduced 2DG analgesia. These effects are discussed in terms of the heterogeneity of pain-inhibitory responses.
急性而非慢性抗抑郁药治疗可增强冷水游泳后的镇痛反应。本研究评估了用去甲丙咪嗪（DMI）进行急性（10毫克/千克）和慢性（10毫克/千克，连续7天每日两次）预处理对大鼠在2-脱氧-D-葡萄糖（2DG）处理后通过跳跃试验测量的镇痛反应的影响。急性而非慢性DMI预处理显著降低了2DG诱导的镇痛作用。根据疼痛抑制反应的异质性对这些效应进行了讨论。
