Joshi V V, Oleske J M, Minnefor A B, Singh R, Bokhari T, Rapkin R H
Pediatr Pathol. 1984;2(1):71-87. doi: 10.3109/15513818409041189.
Biopsy and/or autopsy material from lymphoreticular and other organs was studied in 8 children with suspected acquired immune deficiency syndrome (AIDS). One or both parents of each of these children had one or more of the recognized risk factors for AIDS, such as intravenous drug abuse, prostitution, Haitian origin. The following histologic patterns were noted in the lymph nodes: (1) follicular hyperplasia with normocellular paracortex, (2) follicular hyperplasia with depletion of paracortex, and (3) atrophy of follicles with depletion of paracortex. Lymphoid interstitial pneumonitis (LIP), a previously unreported lesion in AIDS, was present in 4 cases. It is suggested that the pulmonary lymphoid lesion may be part of a more generalized lymphoid hyperplasia involving B cells. The gross and microscopic features of the thymus, available in 2 of the 8 cases, indicated that the immunologic defect in these children was not of congenital type. Pathologic findings can be helpful in the diagnosis of the syndrome when correlated with clinical and immunologic features of suspected cases and of the pulmonary lesion. The latter is of importance in deciding the type of therapy to be given for the pulmonary disease process.
对8名疑似获得性免疫缺陷综合征（艾滋病）儿童的淋巴网状组织及其他器官的活检和/或尸检材料进行了研究。这些儿童的父母一方或双方有一个或多个公认的艾滋病危险因素，如静脉注射毒品、卖淫、海地血统。在淋巴结中观察到以下组织学模式：（1）滤泡增生伴正常细胞副皮质区，（2）滤泡增生伴副皮质区细胞减少，（3）滤泡萎缩伴副皮质区细胞减少。4例出现淋巴细胞间质性肺炎（LIP），这是艾滋病中以前未报道过的病变。提示肺部淋巴病变可能是涉及B细胞的更广泛淋巴增生的一部分。8例中有2例可获得胸腺的大体和显微镜特征，表明这些儿童的免疫缺陷不是先天性的。当病理结果与疑似病例的临床和免疫特征以及肺部病变相关联时，有助于该综合征的诊断。后者对于确定针对肺部疾病进程的治疗类型很重要。
