Stefenelli N, Priessnitz E
Z Gastroenterol. 1978 Apr;16(4):257-60.
Apomorphine in sub-emetic doses inhibits gastric emptying without producing nausea or vomiting. This discovery was applied to 21 persons to find out correlation between gastric emptying rate and alcohol absorption. In the 60 minutes after a single oral ingestion the shape of the alcohol-tolerance curve is considerably flatter after administration of apromorphine as compared to controls. The peak blood alcohol concentration occurs later and is significantly lower. These findings suggest that absorption of ethyl alcohol after a single oral alcohol ingestion can be controlled to a considerable extent by the gastric emptying rate.
亚催吐剂量的阿扑吗啡可抑制胃排空，且不会引起恶心或呕吐。这一发现被应用于21人，以探究胃排空率与酒精吸收之间的相关性。单次口服后60分钟内，与对照组相比，服用阿扑吗啡后酒精耐受曲线的形状明显更平缓。血中酒精浓度峰值出现得更晚，且显著更低。这些发现表明，单次口服酒精后，乙醇的吸收在很大程度上可由胃排空率控制。
