Fellström B, Danielson B G, Karlström B, Lithell H, Ljunghall S, Vessby B, Wide L
Br J Urol. 1984 Jun;56(3):263-9. doi: 10.1111/j.1464-410x.1984.tb05384.x.
The metabolic effects of a high protein diet (HPD) were studied in eight patients with idiopathic recurrent calcium oxalate stones. On the HPD there was a 35% increase in urinary calcium concomitant with increased excretion of cyclic AMP and hydroxyproline. These findings point to an enhanced resorption of bone, possibly secondary to increased renal loss of calcium. The urinary citrate decreased by 25% along with reduced serum standard bicarbonate and urinary pH. The high formation of acid metabolites might also have adverse effects on calcium balance and bone. Urinary oxalate excretion was not affected nor were there any significant changes in the calculated urinary supersaturation of calcium oxalate, if changes in urinary citrate, pH, sulphate, sodium, phosphate and volume were also considered. This study suggests that the possible negative influence on the propensity to form renal stones of a diet rich in animal protein is probably due to reduced urinary inhibitory activity.
对8例特发性复发性草酸钙结石患者进行了高蛋白饮食（HPD）的代谢影响研究。采用高蛋白饮食时，尿钙增加35%，同时环磷酸腺苷和羟脯氨酸排泄增加。这些发现表明骨吸收增强，可能继发于肾钙丢失增加。尿枸橼酸盐减少25%，同时血清标准碳酸氢盐和尿pH值降低。酸性代谢产物的大量生成也可能对钙平衡和骨骼产生不利影响。尿草酸盐排泄未受影响，并且如果同时考虑尿枸橼酸盐、pH值、硫酸盐、钠、磷酸盐和尿量的变化，草酸钙的计算尿饱和度也没有显著变化。本研究表明，富含动物蛋白的饮食对肾结石形成倾向可能产生的负面影响可能是由于尿抑制活性降低。
