Pérez-López F R, Urcia M, Torralba R, Lafarga L, Leal M C, Guillén V, Hergueta J
Rev Esp Oncol. 1984;31(3):401-7.
The administration of cyclophosphamide (200 mg/kg) intraperitoneally produces a high mortality in Wistar rats bearing mammary tumors induced by N-methylnitrosourea. The effect is more marked when the drug is administered at 8:00 A.M. than when given at 2:00 P.M. The injection of cyclophosphamide at 2:00 P.M. slowers the tumor growth, the effect being significative after two weeks compared with the control animals, and after four weeks when compared with the animals receiving the drug at 8:00 A.M.
对由N-甲基亚硝基脲诱导产生乳腺肿瘤的Wistar大鼠腹腔注射环磷酰胺（200毫克/千克）会导致高死亡率。上午8点给药时的效果比下午2点给药时更明显。下午2点注射环磷酰胺会减缓肿瘤生长，与对照动物相比，两周后效果显著，与上午8点给药的动物相比，四周后效果显著。
