Urcia M, Leal M C, Lafarga L, Guillén V, Hergueta J, Pérez-López F R
Rev Esp Oncol. 1984;31(4):601-4.
Wistar rats bearing N-nitrosomethylurea-induced mammary tumors received intratumoral injections of prospidium chloride or saline. Each tumor with 30-100 mm2 (the product of the two largest perpendicular diameters) received 20 mg of prospidium chloride diluted in 100 microliter of saline, and increasing amounts of 20 mg of the product in the same volume for every additional 100 mm2 or fraction of tumor. After a week the treatment was repeated in the same way. Control rats received only saline without prospidium chloride. No significant differences were observed regarding the tumor area, total tumor area/rat, and body weight when comparing the rats receiving prospidium chloride and the control rats. Prospidium chloride does not show any direct oncolytic effect upon the experimental model employed.
携带N-亚硝基甲基脲诱导乳腺肿瘤的Wistar大鼠接受瘤内注射氯化丙哌卡因或生理盐水。每处面积为30 - 100平方毫米（两条最大垂直直径的乘积）的肿瘤接受用100微升生理盐水稀释的20毫克氯化丙哌卡因，肿瘤面积每增加100平方毫米或其部分，就在相同体积中增加20毫克该药物。一周后以相同方式重复治疗。对照大鼠仅接受不含氯化丙哌卡因的生理盐水。比较接受氯化丙哌卡因的大鼠和对照大鼠时，在肿瘤面积、每只大鼠的肿瘤总面积以及体重方面未观察到显著差异。氯化丙哌卡因对所采用的实验模型未显示出任何直接的溶瘤作用。
