Pérez-López F R, Guillén V, Hergueta J, Lafarga L, Uurcia M
Rev Esp Oncol. 1984;31(4):583-9.
The chemotherapeutic effectiveness of intraperitoneal administration of cyclophosphamide (CY) (100 mg/kg) was evaluated, on a circadian basis, on the N-nitrosomethylurea (NMU)-induced mammary tumors in female Wistar rats. Untreated rats showed a progressive increase in the mean tumor number/rat, tumor area and total tumor area/rat. The average number of tumors/rat was significantly lower in the rats treated with CY at 02:00 h than the values obtained in the control group days 21 and 28, and than that observed at the end of the 4-week period of study in the rats treated with CY at 20:00 h. Average tumor area and total tumor area/rat in all groups of treated rats were lower than those in the untreated animals, though without significant differences amongst those treated with CY. The body weight remained constant throughout the 4-week period of study in the control group, while a transient reduction was registered after CY administration.
在雌性Wistar大鼠中，基于昼夜节律评估了腹腔注射环磷酰胺（CY）（100毫克/千克）对N-亚硝基甲基脲（NMU）诱导的乳腺肿瘤的化疗效果。未治疗的大鼠平均每只大鼠的肿瘤数量、肿瘤面积和每只大鼠的总肿瘤面积呈逐渐增加趋势。在02:00时接受CY治疗的大鼠每只大鼠的平均肿瘤数量显著低于对照组在第21天和第28天的值，也低于在20:00时接受CY治疗的大鼠在4周研究期结束时观察到的值。所有接受治疗的大鼠组的平均肿瘤面积和每只大鼠的总肿瘤面积均低于未治疗的动物，但接受CY治疗的组之间无显著差异。对照组在整个4周研究期内体重保持恒定，而在给予CY后体重出现短暂下降。
