“ZSTATS”——一种针对潜在Z-DNA序列的统计分析方法。
'ZSTATS'--a statistical analysis for potential Z-DNA sequences.
作者信息
Vass J K, Wilson R H
出版信息
Nucleic Acids Res. 1984 Jan 11;12(1 Pt 2):825-32. doi: 10.1093/nar/12.1part2.825.
Abstract
We have developed a FORTRAN programme for scanning DNA sequences for potential Z-DNA forming regions using the One-Sample Runs Test. The programme also detects other non-random arrangements of purines and pyrimidines on the same strand and will detect purine- or pyrimidine-rich strands and G:C- or A:T-rich regions. A series of test statistics are produced as a graphical output and these have been used to search a number of beta- type globin DNA sequences for potential Z-DNA regions whose biological significance is briefly discussed.
摘要
我们已经开发了一个FORTRAN程序，用于使用单样本游程检验扫描DNA序列以寻找潜在的Z-DNA形成区域。该程序还能检测同一条链上嘌呤和嘧啶的其他非随机排列，并且能检测富含嘌呤或嘧啶的链以及富含G:C或A:T的区域。一系列检验统计量以图形输出形式生成，并且已被用于在多个β型珠蛋白DNA序列中搜索潜在的Z-DNA区域，本文还简要讨论了这些区域的生物学意义。
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