Maliwan N, Reid R W, Katzen R B
Arch Pathol Lab Med. 1984 Feb;108(2):108-11.
Gas-liquid chromatography was performed on serum samples obtained from selected patients with infectious diseases. The characteristic chromatographic profile was seen in serum samples from 21 patients with either documented invasive candidiasis or candidemia. Serum samples from ten normal controls, three patients with candidal colonization, and 11 clinically noninfected patients, seven of whom had fevers attributable to malignancies, showed normal chromatograms. The eradication of Candida from deep tissue and/or bloodstream was reflected promptly by a normalization of the chromatograms in all six cases. Use of amphotericin B was safely avoided in three patients with candidemia whose follow-up chromatograms became normal following the discontinuation of intravenous catheterization. This test promises to be useful in the diagnosis and therapeutic monitoring of invasive candidal infections and candidemia.
对从选定的传染病患者获取的血清样本进行了气液色谱分析。在21例确诊为侵袭性念珠菌病或念珠菌血症的患者的血清样本中观察到了特征性色谱图。来自10名正常对照者、3名念珠菌定植患者以及11名临床未感染患者（其中7名因恶性肿瘤发热）的血清样本显示色谱图正常。在所有6例病例中，深部组织和/或血流中念珠菌的清除迅速通过色谱图的正常化得到反映。3例念珠菌血症患者在停用静脉导管后随访色谱图恢复正常，从而安全地避免了使用两性霉素B。该检测有望用于侵袭性念珠菌感染和念珠菌血症的诊断及治疗监测。
