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PHARM——一款用于个体和群体药代动力学参数估计的交互式图形程序。

PHARM--an interactive graphic program for individual and population pharmacokinetic parameter estimation.

作者信息

Gomeni R

出版信息

Comput Biol Med. 1984;14(1):25-34. doi: 10.1016/0010-4825(84)90017-9.

DOI:10.1016/0010-4825(84)90017-9
PMID:6546907
Abstract

This paper describes a new computer program PHARM to estimate individual or population pharmacokinetic parameters in nonlinear models. PHARM is an interactive program which uses graphic facilities to display data and results. The structural model can be defined using differential or integrated equations. The user can also define an error model associated with experimental data. The nonlinear mixed effect model is used to estimate the mean population parameters and their interindividual variability. The maximum likelihood and Bayesian criteria are used to estimate simultaneously the error and structural model parameters.

摘要

本文描述了一种新的计算机程序PHARM，用于估计非线性模型中的个体或群体药代动力学参数。PHARM是一个交互式程序，它使用图形工具来显示数据和结果。结构模型可以使用微分方程或积分方程来定义。用户还可以定义与实验数据相关的误差模型。非线性混合效应模型用于估计总体平均参数及其个体间变异性。最大似然法和贝叶斯准则用于同时估计误差和结构模型参数。

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