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1
Production of C-24- and C-23-oxidized metabolites of 1,25-dihydroxycholecalciferol by cultured kidney cells (LLC PK1) and their presence in kidney in vivo.培养的肾细胞（LLC PK1）产生1,25-二羟基胆钙化醇的C-24和C-23氧化代谢产物及其在体内肾脏中的存在情况。
Biochem J. 1984 May 1;219(3):713-7. doi: 10.1042/bj2190713.
2
(23S)-1,23,25-Trihydroxycholecalciferol, an intestinal metabolite of 1,25-dihydroxycholecalciferol.（23S）-1,23,25-三羟基胆钙化醇，1,25-二羟基胆钙化醇的一种肠道代谢产物。
Biochem J. 1983 Jul 15;214(1):261-4. doi: 10.1042/bj2140261.
3
Decreased 1,25-dihydroxycholecalciferol and increased 25-hydroxy- and 24,25-dihydroxycholecalciferol in tissues of rats treated with thyroxine.用甲状腺素处理的大鼠组织中1,25 - 二羟胆钙化醇减少，25 - 羟胆钙化醇和24,25 - 二羟胆钙化醇增加。
Calcif Tissue Int. 1981;33(4):445-7. doi: 10.1007/BF02409469.
4
C(24)- and C(23)-oxidation, converging pathways of intestinal 1,25-dihydroxyvitamin D3 metabolism: identification of 24-keto-1,23,25-trihydroxyvitamin D3.
Biochemistry. 1983 Dec 6;22(25):5848-53. doi: 10.1021/bi00294a025.
5
Evidence for 24,25-dihydroxycholecalciferol receptors in long bones of newborn rats.新生大鼠长骨中24,25-二羟胆钙化醇受体的证据。
Biochem J. 1982 Apr 15;204(1):31-6. doi: 10.1042/bj2040031.
6
23, 25, 26-trihydroxycholecalciferol. A 25-hydroxycholecalciferol-26,23-lactone precursor.23,25,26-三羟基胆钙化醇。一种25-羟基胆钙化醇-26,23-内酯前体。
Biochem J. 1982 Jul 15;206(1):173-6. doi: 10.1042/bj2060173.
7
Characterization of the metabolic pathway of 1,25-dihydroxy-16-ene vitamin D3 in rat kidney by on-line high performance liquid chromatography-electrospray tandem mass spectrometry.利用在线高效液相色谱-电喷雾串联质谱法对大鼠肾脏中1,25-二羟基-16-烯维生素D3代谢途径的表征
Biochem Pharmacol. 1995 Apr 18;49(8):1099-710. doi: 10.1016/0006-2952(95)98507-6.
8
The stimulation of 1,25-dihydroxycholecalciferol metabolism in vitamin D-deficient rats by 1,25-dihydroxycholecalciferol treatment.1,25 - 二羟胆钙化醇治疗对维生素D缺乏大鼠1,25 - 二羟胆钙化醇代谢的刺激作用。
J Clin Invest. 1973 Mar;52(3):543-8. doi: 10.1172/JCI107214.
9
Differentiation-related pathways of 1 alpha,25-dihydroxycholecalciferol metabolism in human colon adenocarcinoma-derived Caco-2 cells: production of 1 alpha,25-dihydroxy-3epi-cholecalciferol.人结肠腺癌来源的Caco-2细胞中1α,25-二羟基胆钙化醇代谢的分化相关途径：1α,25-二羟基-3-表胆钙化醇的产生
Exp Cell Res. 1998 May 25;241(1):194-201. doi: 10.1006/excr.1998.4044.
10
Synthesis of 1 alpha-hydroxy[7-3H]cholecalciferol and its metabolism in the chick.1α-羟基[7-³H]胆钙化醇的合成及其在雏鸡体内的代谢
Biochem J. 1978 Oct 15;176(1):111-7. doi: 10.1042/bj1760111.

本文引用的文献

1
Regulation of the metabolism of vitamin D.维生素D代谢的调节
Physiol Rev. 1980 Apr;60(2):551-613. doi: 10.1152/physrev.1980.60.2.551.
2
1 alpha,25-Dihydroxyvitamin D3 induces differentiation of human myeloid leukemia cells.1α,25-二羟基维生素D3诱导人髓系白血病细胞分化。
Biochem Biophys Res Commun. 1981 Oct 15;102(3):937-43. doi: 10.1016/0006-291x(81)91628-4.
3
Differentiation of mouse myeloid leukemia cells induced by 1 alpha,25-dihydroxyvitamin D3.1α,25-二羟基维生素D3诱导小鼠髓系白血病细胞分化
Proc Natl Acad Sci U S A. 1981 Aug;78(8):4990-4. doi: 10.1073/pnas.78.8.4990.
4
Stereochemistry of 25-hydroxyvitamin D3-26,23-lactone and 1 alpha, 25-dihydroxyvitamin D3-26,23-lactone in rat serum.大鼠血清中25-羟基维生素D3-26,23-内酯和1α,25-二羟基维生素D3-26,23-内酯的立体化学
FEBS Lett. 1981 Nov 16;134(2):207-11. doi: 10.1016/0014-5793(81)80603-5.
5
Isolation and identification of 1 alpha- and 23-hydroxylated metabolites of 25-hydroxy-24-oxovitamin D3 from in vitro incubates of chick kidney homogenates.从鸡肾匀浆的体外孵育物中分离并鉴定25-羟基-24-氧代维生素D3的1α-和23-羟基化代谢产物。
J Biol Chem. 1983 Jan 10;258(1):457-63.
6
C(24)- and C(23)-oxidation, converging pathways of intestinal 1,25-dihydroxyvitamin D3 metabolism: identification of 24-keto-1,23,25-trihydroxyvitamin D3.
Biochemistry. 1983 Dec 6;22(25):5848-53. doi: 10.1021/bi00294a025.
7
(23S)-1,23,25-Trihydroxycholecalciferol, an intestinal metabolite of 1,25-dihydroxycholecalciferol.（23S）-1,23,25-三羟基胆钙化醇，1,25-二羟基胆钙化醇的一种肠道代谢产物。
Biochem J. 1983 Jul 15;214(1):261-4. doi: 10.1042/bj2140261.
8
Intestinal synthesis of 24-keto-1,25-dihydroxyvitamin D3. A metabolite formed in vivo with high affinity for the vitamin D cytosolic receptor.
J Biol Chem. 1983 Aug 10;258(15):9100-7.
9
Stereochemistry of naturally-occurring 25-hydroxyvitamin D3-26,23 lactone as determined by radioligand binding analysis and high-performance liquid chromatography.通过放射性配体结合分析和高效液相色谱法测定天然存在的25-羟基维生素D3-26,23内酯的立体化学
Biochem Biophys Res Commun. 1982 Sep 30;108(2):541-6. doi: 10.1016/0006-291x(82)90862-2.
10
23-keto-25-hydroxyvitamin D3 and 23-keto-1,25-dihydroxyvitamin D3: two new vitamin D3 metabolites with high affinity for the 1,25-dihydroxyvitamin D3 receptor.
Biochem Biophys Res Commun. 1982 Aug 31;107(4):1319-25. doi: 10.1016/s0006-291x(82)80142-3.

培养的肾细胞（LLC PK1）产生1,25-二羟基胆钙化醇的C-24和C-23氧化代谢产物及其在体内肾脏中的存在情况。

Production of C-24- and C-23-oxidized metabolites of 1,25-dihydroxycholecalciferol by cultured kidney cells (LLC PK1) and their presence in kidney in vivo.

作者信息

Napoli J L, Martin C A

出版信息

Biochem J. 1984 May 1;219(3):713-7. doi: 10.1042/bj2190713.

DOI:10.1042/bj2190713
PMID:6547601
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1153536/
Abstract

1,25-Dihydroxy[3H]cholecalciferol was converted into several more-polar metabolites by a cultured pig kidney cell line (LLC PK1). The production of metabolites was stimulated by pretreating the cells with unlabelled 1,25-dihydroxycholecalciferol. A similar profile of metabolites was observed on high-pressure-liquid-chromatographic analysis of an extract from the kidneys of rats dosed intravenously with 1,25-dihydroxy[3H]cholecalciferol. Among the metabolites detected were 1,24,25-trihydroxycholecalciferol, 1,25-dihydroxy-24-oxocholecalciferol, 1,23,25-trihydroxy-24-oxocholecalciferol and 1,25-dihydroxycholecalciferol-26,23-lactone. The results are in accord with data reported for intestinal 1,25-dihydroxycholecalciferol metabolism [Napoli, Pramanik, Royal, Reinhardt & Horst (1983) J. Biol. Chem. 258, 9100-9107]. These data indicate that C-23- and C-24-oxidation of 1,25-dihydroxycholecalciferol are phenomena common to calciferol target tissues, and that regulation of 1,25-dihydroxycholecalciferol homoeostasis is dependent on the rate of its metabolism in addition to the rate of its synthesis.

摘要

1,25-二羟基[3H]胆钙化醇被一种培养的猪肾细胞系（LLC PK1）转化为几种极性更强的代谢产物。用未标记的1,25-二羟基胆钙化醇预处理细胞可刺激代谢产物的产生。对静脉注射1,25-二羟基[3H]胆钙化醇的大鼠肾脏提取物进行高压液相色谱分析时，观察到了类似的代谢产物谱。检测到的代谢产物包括1,24,25-三羟基胆钙化醇、1,25-二羟基-24-氧代胆钙化醇、1,23,25-三羟基-24-氧代胆钙化醇和1,25-二羟基胆钙化醇-26,23-内酯。这些结果与报道的肠道1,25-二羟基胆钙化醇代谢的数据一致[那不勒斯、普拉马尼克、罗亚尔、莱因哈特和霍斯特（1983年）《生物化学杂志》258, 9100 - 9107]。这些数据表明，1,25-二羟基胆钙化醇的C-23和C-24氧化是维生素D靶组织共有的现象，并且1,25-二羟基胆钙化醇稳态的调节除了取决于其合成速率外，还取决于其代谢速率。