Llupiá J, Lumachi B, Beckett P R, Roberts D J
Arzneimittelforschung. 1984;34(10A):1373-5.
In man, the reflux of duodenal contents into the stomach leads to gastritis and produces a mucosa susceptible to ulceration. This effect, predominantly due to bile acids, was studied in an animal model in which the oral administration of bile (ox bile powder containing a minimum of 45% cholic acid) markedly increased the gastrolesive action of subcutaneous indomethacin in the pylorus-ligated rat. Oral administration of the new antacid almagate (hydrated aluminium-magnesium hydroxycarbonate, Al2Mg6(OH)14 (CO3)2 X 4 H2O, Almax) gave a significant dose-related reduction in the severity of bile-facilitated gastric lesions whereas aluminium hydroxide gel did not. The antiulcer activity of almagate in this model is presumed to be attributable to its ability to sequester and inactivate bile acids at the pH of the stomach contents, an effect which should beneficially contribute to its acid-neutralising property in the treatment of gastritis, peptic ulcer and associated conditions.
在人类中，十二指肠内容物反流至胃会导致胃炎，并产生易发生溃疡的黏膜。这种作用主要归因于胆汁酸，在一种动物模型中对此进行了研究，在该模型中，口服胆汁（含有至少45%胆酸的牛胆汁粉）显著增强了皮下注射消炎痛对幽门结扎大鼠的胃损伤作用。口服新型抗酸剂铝镁加（水合铝镁羟基碳酸盐，Al2Mg6(OH)14(CO3)2·4H2O，Almax）可使胆汁促进的胃损伤严重程度呈剂量依赖性显著降低，而氢氧化铝凝胶则无此作用。铝镁加在该模型中的抗溃疡活性据推测归因于其在胃内容物pH值下螯合和灭活胆汁酸的能力，这种作用应有助于其在治疗胃炎、消化性溃疡及相关病症时的酸中和特性发挥有益作用。
