Younge B R, Buski Z J
Can J Ophthalmol. 1976 Oct;11(4):295-9.
The tonic pupil has a typical appearance and characteristic reactions to both light and the near reflex. Testing with Mecholyl (methacholine) is not possible since the drug is no longer manufactured. The reactions of a group of 25 patients with tonic pupil were studied using dilute pilocarpine, and compared with the pupil responses of a separate control group. We found that concentrations of 0.2% pilocarpine produced too many false-positive reactions in the control group and that 0.05% pilocarpine produced an insufficient response. The 0.1% concentration seemed suitable for ordinary clinical examinations and is recommended for pharmacologic confirmation of the diagnosis of tonic (Adie's) pupil.
强直性瞳孔有典型的外观以及对光和近反射的特征性反应。由于不再生产该药物，因此无法使用乙酰甲胆碱（醋甲胆碱）进行检测。我们使用稀释的毛果芸香碱对一组25例强直性瞳孔患者的反应进行了研究，并与另一对照组的瞳孔反应进行了比较。我们发现，0.2%毛果芸香碱浓度在对照组中产生了过多的假阳性反应，而0.05%毛果芸香碱浓度产生的反应不足。0.1%的浓度似乎适用于普通临床检查，建议用于强直性（阿迪氏）瞳孔诊断的药理学确认。
