Avery D, Winokur G
Arch Gen Psychiatry. 1978 Jun;35(6):749-53. doi: 10.1001/archpsyc.1978.01770300091010.
Suicide, attempted suicide, and relapse rates in 519 depressives were examined, comparing the effects of different treatments. After six months, suicide attempts were seen significantly less frequently in the ECT groups (0.8%) than in the antidepressant group (4.2%) or the "adequate" antidepressant subgroup (7.0%) Fewer suicide attempts occurred in the ECT group compared to the antidepressant group among both in those who had attempted suicide prior to admission (0% vs 10%) and in those who had not (1.1% vs 3.6%). A history of attempted suicide showed a greater risk of both suicide (2.9%) in the following year and subsequent suicide attempt (5.9%). A depressive diagnosis may be as good a predictor of suicidal behavior as a history of attempted suicide. Relapse rates did not differ between treatment groups.
对519名抑郁症患者的自杀、自杀未遂及复发率进行了研究,比较不同治疗方法的效果。六个月后,接受电休克治疗(ECT)的组中自杀未遂的发生率(0.8%)显著低于抗抑郁药组(4.2%)或“足量”抗抑郁药亚组(7.0%)。在入院前有过自杀未遂经历的患者中,ECT组的自杀未遂发生率低于抗抑郁药组(0% 对10%);在无自杀未遂经历的患者中,ECT组的自杀未遂发生率也低于抗抑郁药组(1.1% 对3.6%)。有自杀未遂史的患者在次年出现自杀(2.9%)及后续自杀未遂(5.9%)的风险更高。抑郁症诊断对于自杀行为的预测作用可能与自杀未遂史相当。各治疗组之间的复发率没有差异。