实验性糖尿病中血视网膜屏障的改变。
Alteration of the blood-retinal barrier in experimental diabetes mellitus.
作者信息
Waltman S, Krupin T, Hanish S, Oestrich C, Becker B
出版信息
Arch Ophthalmol. 1978 May;96(5):878-9. doi: 10.1001/archopht.1978.03910050480018.
Abstract
Vitreous fluorophotometry was used to evaluate the integrity of the blood-retinal barrier to fluorescein in hooded rats. Streptozotocin-induced diabetes mellitus caused a breakdown of this barrier within ten days. Normalization of blood glucose levels with insulin significantly reduced (P less than .005) the increased permeability. This functional microangiopathy might prove to be the earliest detectable change in the retinal circulation in experimental diabetes.
摘要
采用玻璃体荧光光度测定法评估带帽大鼠血视网膜屏障对荧光素的完整性。链脲佐菌素诱导的糖尿病在十天内导致该屏障破坏。用胰岛素使血糖水平正常化可显著降低（P小于0.005）通透性增加。这种功能性微血管病变可能是实验性糖尿病视网膜循环中最早可检测到的变化。
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