Cunha-Vaz J, Faria de Abreu J R, Campos A J
Br J Ophthalmol. 1975 Nov;59(11):649-56. doi: 10.1136/bjo.59.11.649.
The blood-retinal barrier plays an important part in the processes of retinal pathophysiology. A new clinical method for the study of the blood-retinal barrier by vitreous fluorophotometry appears to satisfy the necessary requirements in that it is quantitative and shows good reproducibility and high sensitivity. The application of this method to a series of diabetic patients with apparently "normal" fundi revealed the presence of a significant breakdown of the blood-retinal barrier in the early stages of retinal involvement in diabetes. The extent of the breakdown can be measured allowing for comparative and evolutionary evaluations. The disturbance of the blood-retinal barrier, as evidence by vitreous fluorophotometry, appears before microaneurysms or capillary closure can be demonstrated by fluorescein angiography.
血视网膜屏障在视网膜病理生理过程中起重要作用。一种通过玻璃体荧光光度法研究血视网膜屏障的新临床方法似乎满足必要要求，因为它是定量的，具有良好的可重复性和高灵敏度。将该方法应用于一系列眼底看似“正常”的糖尿病患者，发现在糖尿病视网膜病变早期血视网膜屏障就已出现明显破坏。可以测量破坏程度，以便进行比较和动态评估。玻璃体荧光光度法显示的血视网膜屏障紊乱，出现在荧光素血管造影能显示微动脉瘤或毛细血管闭塞之前。
