绿海龟（蠵龟）的胆汁盐。
Bile salts of the green turtle Chelonia mydas (L.).
作者信息
Haslewood G A, Ikawa S, Tökés L, Wong D
出版信息
Biochem J. 1978 May 1;171(2):409-12. doi: 10.1042/bj1710409.
Abstract
- Bile salts of the green turtle Chelonia mydas (L.) were analysed as completely as possible. 2. They consist of taurine conjugates of 3 alpha, 7 alpha, 12 alpha, 22 xi-tetrahydroxy-5 beta-cholestan-26-oic acid (tetrahydroxysterocholanic acid) and 3 alpha 12 alpha, 22 xi-trihydroxy-5 beta-cholestan-26-oic acid, with minor amounts of 3 alpha, 7 alpha, 12 alpha-trihydroxy-5beta-cholan-24-oic acid (cholic acid), 3alpha, 12 alpha-dihydroxy-5beta-cholan-24-oic acid (deoxycholic acid) and possibly other bile acids. 3. Cholic acid and deoxycholic acid represent the first known examples of bile acids common to chelonians and other animal forms: they may indicate independent evolution in chelonians to C24 bile acids. 4. The discovery of a 7-deoxy C27 bile acid is the first evidence that C27 bile acids or their conjugates have an enterohepatic circulation.
摘要
- 对绿海龟（蠵龟）的胆汁盐进行了尽可能全面的分析。2. 它们由3α、7α、12α、22ξ-四羟基-5β-胆甾烷-26-酸（四羟基甾胆烷酸）和3α、12α、22ξ-三羟基-5β-胆甾烷-26-酸的牛磺酸共轭物组成，还有少量的3α、7α、12α-三羟基-5β-胆烷-24-酸（胆酸）、3α、12α-二羟基-5β-胆烷-24-酸（脱氧胆酸）以及可能的其他胆汁酸。3. 胆酸和脱氧胆酸是已知的龟类和其他动物形式共有的胆汁酸的首个例子：它们可能表明龟类中向C24胆汁酸的独立进化。4. 7-脱氧C27胆汁酸的发现是C27胆汁酸或其共轭物具有肠肝循环的首个证据。
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